Xiidra (lifitegrast ophthalmic solution) 5% is a prescription eye drop used to treat the signs and symptoms of dry eye disease. Please click About Xiidra for more info.
If you wear contact lenses, remove before using Xiidra and wait 15 minutes before placing them back in your eyes.
Eligible commercially insured patients may pay as little as $0 on their first 90-day prescription and as little as $0 for each refill with a Xiidra Savings Card. Please click Cost & Savings for more info.
Xiidra may start to deliver long-term symptom relief for some patients in just two weeks, with continued twice-daily use.*
Yes! Xiidra is covered for nearly 7 out of 10† patients with Medicare prescription coverage. Please click Cost & Savings for more info.
†Based on MMIT data from January 2026. Up to 79% of commercial and 70% of Medicare Part D patients may be covered.
The most common side effects of Xiidra are usually mild to moderate and related to the eyes or taste.
Many of the common side effects of Xiidra are temporary and may improve over time.
Yes. Please reach out to your eye care doctor to see if Xiidra is right for you.
Some patients may experience blurry vision and headaches. In clinical studies, these adverse reactions were experienced in 1% - 5% of patients taking Xiidra. Experiencing dizziness may be a possible side effect with Xiidra in certain patients. Stop taking Xiidra and seek medical care right away if you experience symptoms of an allergic reaction, including difficulty breathing or swallowing or swollen tongue.
Xiidra targets a source of inflammation that can cause chronic dry eye.
Please click About Xiidra for more info.
In a study, a total of nine (9) of the 47 patients (19%) had blood concentrations of lifitegrast above 0.5 ng/mL (the lower limit of assay quantitation). Overall, there was no evidence of accumulation of lifitegrast in blood plasma over the course of the study, with most concentrations below the limit of detection on days 180 and 360.
Xiidra is a sterile, clear colorless to slight brownish-yellow eye drop solution. Xiidra contains Active: lifitegrast 50 mg/mL; Inactives: sodium chloride, sodium phosphate dibasic anhydrous, sodium thiosulfate pentahydrate, sodium hydroxide and/or hydrochloric acid (to adjust pH) and water for injection.
Yes! Please click About Xiidra to see Julie’s testimonial.
Xiidra is used to treat the signs and symptoms of dry eye disease, but some people may notice temporary eye discomfort when using the drops.
No! Xiidra is a nonsteroid anti-inflammatory prescription medication.
Xiidra (lifitegrast ophthalmic solution) 5% is a prescription eye drop used to treat the signs and symptoms of dry eye disease.
Do not use Xiidra if you are allergic to any of its ingredients. Seek medical care immediately if you get any symptoms of an allergic reaction.
The most common side effects of Xiidra include eye irritation, discomfort or blurred vision when the drops are applied to the eyes, and an unusual taste sensation.